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Small cell lung cancer (SCLC) accounts for approximately 15% of all lung cancers and demands effective targeted therapeutic strategies. In this meta analysis study, we aim to identify significantly mutated genes and regulatory pathways to help us better understand the

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In vivo functional brain mapping in a conditional mouse

In vivo functional brain mapping in a conditional mouse model of human tauopathy (tau p301l) reveals reduced neural activity in memory formation structures Pablo D Perez , 1 Gabrielle Hall , 1 Tetsuya Kimura , 3 Yan Ren , 2 Rachel M Bailey , 2 Jada Lewis , 2 Marcelo Febo , 1 and Naruhiko Sahara 2

In vivo functional brain mapping in a conditional mouse

Feb 04, 2013 · Tauopathies are characterized by intracellular deposition of the microtubule associated protein tau as filamentous aggregates. The rTg4510 mouse conditionally ees mutant human tau protein in various forebrain areas under the Tet off eion system. Mice develop neurofibrillary tangles, with significant neuronal loss and cognitive deficits by 6 months of age. Previous behavioral


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In vivo functional brain mapping in a conditional mouse

Methodological considerations. We closely analyzed the intensity histograms of rTg4510 and control mice (histograms in Figure Figure1B). 1 B). The probability of finding voxels with a Z score of 1 or more was less than 5% (p < 0.05; Figure Figure1B 1 B bottom graph inset).This corresponds to 7.9% of the total population of brain voxels for rTg4510 mice and 10.6% for nonTg mice (unpaired t test

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Sciences. The University of Tokyo, Tokyo 113 8657 JAPAN. In "social buffering", a phenomenon known in various species, stress responses are less distinct when an animal is exposed to a stressor with one or more conspecific animals. We have


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